Synthesis of alkoxy-isoflavones as potential ?-glucosidase inhibitors
نویسندگان
چکیده
The aim of the present study was to synthesize isoflavone-enaminones 3a-c and 7-alkoxy-isoflavones 4a-c, evaluate their inhibition ?-glucosidase, analyze bioisosteric effect presence versus absence aromatic moieties in these benzopyran derivatives. All test compounds exhibited greater ?-glucosidase than positive control acarbose. series isoflavones 4a-c showed higher inhibitory activity (IC50 = 6.3–87.6 µM) parental 7-hydroxyisoflavones 2a-c 109.4–173.2 µM), suggesting that attachment a 4’-chloroacetophenone moiety 7-hydroxyl group is an efficient way increase ?-glucosidase. Furthermore, 3 4 enhance by hydrophobic effects, according docking calculations.
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ژورنال
عنوان ژورنال: Medicinal Chemistry Research
سال: 2022
ISSN: ['1554-8120', '1054-2523']
DOI: https://doi.org/10.1007/s00044-022-02910-1